Individuals with stable coronary artery disease, or stable angina, experience chest pain on exertion when narrowed or blocked arteries reduce the supply of oxygen-rich blood to the heart muscle. Current treatment calls for lifestyle changes and optimal medical therapy that… Read More ›
Evidence-Based Medicine
Author Insights: Much Variation Seen in How Frequently Additional Surgery After Lumpectomy Is Needed
As many as two-thirds of women with breast cancer who have surgical treatment opt for removal of the affected tissue while preserving as much of the breast as possible, rather than undergo a complete mastectomy. Sometimes the patients who undergo… Read More ›
An “AIDS-Free Generation” Is Within World’s Grasp, Says Hillary Clinton
Citing advances in scientifically proven strategies to treat and prevent HIV/AIDS, US Secretary of State Hillary Clinton called on the world community to join the United States in creating “an AIDS-free generation.” Speaking today at the National Institutes of Health… Read More ›
Using Annual Chest X-Rays to Screen for Lung Cancer Doesn’t Reduce Mortality
Patients who received annual chest radiography for 4 years were no less likely to die of lung cancer than those who received usual care, according to findings from a large randomized trial published online today in JAMA. In an accompanying… Read More ›
FDA Backpedaling on Plan to Withdraw Drug for Low Blood Pressure?
Efforts by the US Food and Drug Administration (FDA) to withdraw from the market a drug to treat low blood pressure that received approval 15 years ago through the agency’s accelerated-approval process appear stalled. The drug, midodrine hydrochloride, was approved… Read More ›
Author Insights: Off-Label Use of Antipsychotics Helpful for Only a Few Conditions
While off-label use of atypical antipsychotics has skyrocketed in recent years, such treatment is beneficial for only a handful of conditions, an analysis published today in JAMA found. The US Food and Drug Administration has approved the use of atypical… Read More ›
Trial Finds Medical Therapy Alone Best for Stroke Patients
Patients who have experienced a stroke are more likely to benefit from receiving aggressive medical therapy alone than receiving such therapy plus the insertion of a stent to reopen a blocked intracranial artery, according to results of an important randomized… Read More ›
A Mixed Reception for NIH Conflict-of-Interest Rules
A long-awaited update to the National Institutes of Health (NIH) rules governing conflicts of interest requires institutions receiving federal funding to disclose more detail about their investigators’ financial relationships with industry. Since the previous set of rules was established in… Read More ›
Proposed Rules Would Boost Human Research Protections
Proposed changes to US oversight of human research would extend existing protections to studies not receiving federal funding and offer individuals more control over how their tissues are used in research, according to Department of Health and Human Services (DHHS)… Read More ›
Analysis Finds Care Suffers During July Turnover
Patients may want to avoid hospitalization during July, if possible, when the annual turnover of medical trainees occurs. The reason: the change is associated with an increase in mortality rates and a decrease in the efficiency of care, according to… Read More ›