Researchers have pinpointed variations in 2 genes that can help predict which women at high risk of breast cancer will respond to preventive treatment. The findings represent a major step toward personalized breast cancer prevention therapy, the study authors said…. Read More ›
Genetics
Genetic Testing Is Vastly Underused, Study Shows
Members of families with a history of certain cancers may miss out on potentially life-saving screening tests or treatment because many forego genetic testing to estimate their cancer risk, according to researchers in France. Investigators from cancer centers throughout France… Read More ›
Angelina Jolie’s Gene Testing, Preventive Mastectomy Highlight Complex Questions for Women With Family History of Cancer
Earlier this week, Academy Award–winning actress Angelina Jolie candidly shared her choices in a New York Times op-ed about being tested for gene mutations that increase the risk of breast cancer and having a preventive mastectomy after testing positive. In… Read More ›
Genetic Testing Recommendations Contradict Professional Ethics, Experts Say
Recent recommendations that advise laboratories and physicians how to tell patients about incidental findings in genetic tests contradict ethical clinical practice, according to bioethicists at Stanford University’s Center for Biomedical Ethics in California. A working group convened by the American… Read More ›
Clinical Score Still Best at Predicting Late Breast Cancer Recurrence
For women who have early-stage breast cancer, examining the clinical characteristics of tumors and the treatment they have been given is more effective than new genetic tests in predicting the likelihood of a recurrence more than 5 years after diagnosis,… Read More ›
Author Insights: Sequencing May One Day Help Pinpoint the Specific Microbe Causing a Bacterial Infection
When a patient develops signs of a bacterial infection, clinicians often send a specimen to a laboratory to see if the illness-causing culprit can be identified. This process typically involves trying to coax bacteria from the specimen to grow in… Read More ›
Teens With Genetic Risk Factors More Likely to Become Heavy Smokers
Teens who have certain genetic risk factors associated with smoking are not more likely to try cigarettes, but when they do, they are more likely to smoke daily and heavily and to pick up the habit more quickly than those… Read More ›
Geneticists Recommend Disclosing “Incidental” Findings for Certain Disorders
When sequencing an individual’s DNA for a particular medical issue uncovers genetic variants that may suggest that the patient may develop other health problems, it presents laboratories and clinicians with a dilemma: should patients be told? Today a prominent group… Read More ›
Cancer Onset in Old Age May Also Signal a Potential Hereditary Risk for Patient’s Family Members
Many people are aware that when an individual develops cancer, especially an early-onset cancer, that event often signals that family members may have a hereditary risk for the malignancy. Now, new research underscores that the appearance of cancer later in… Read More ›
Sugary Drinks Linked With Genetic Susceptibility to Obesity
Researchers have shown that an interaction between a genetic tendency toward obesity and high consumption of sugar-sweetened beverages increases the likelihood of becoming obese. The researchers, whose findings appear online today in the New England Journal of Medicine, calculated body… Read More ›