Most medical interventions have modest effects, and studies that suggest big effects are usually small and are eventually proven wrong, according to an analysis of medical studies published in JAMA today. Studies that appear to demonstrate that a medication or… Read More ›
Statistics and Research Methods
Chimpanzees Aren’t Necessary for Most Research, Says IOM
The era of the chimpanzee as a research tool in federally funded biomedical studies has, for the most part, come to an end. After 9 months of meetings, workshops, and an unprecedented number of public comments, an Institute of Medicine… Read More ›
Changes in Access to Death Data May Impede Medical Research
Certain types of biomedical research will be compromised by a change by the US Social Security Administration (SSA) in its policies regarding public release of death records, said Eugene H. Blackstone, MD, director of clinical investigations in the department of… Read More ›
Study Sheds Light on How Interrupted Sleep May Hamper Memory
Sleeping uninterrupted for a certain duration may be necessary to retain new memories, scientists from Stanford University have discovered in a study in mice involving a new technique called optogenetics, which makes it possible to stimulate specific brain cells. The… Read More ›
Author Insights: Some Clinical Trials Intended for Drug Marketing, Not Advancing Science
A report appearing today in the Archives of Internal Medicine uses court documents related to a product liability lawsuit to detail the running of a “seeding trial.” Such trials, which occur after a drug is approved, are primarily conducted to… Read More ›
Author Insights: Beware of Overestimating Biomarker Validity
Researchers and clinicians often use such biomarkers as the presence of a gene variant, the amount of an enzyme in the blood, or a physical trait measured in imaging studies as indicators of an individual’s risk of developing a disease,… Read More ›
How Risk Statistics Are Presented May Mislead
The way in which many clinical studies present risk may mislead clinicians and patients about the magnitude of a treatment’s benefit and hamper their ability to make informed decisions, according to a Cochrane systematic review published today. The review from… Read More ›